Chemical genetic approaches for the elucidation of signaling pathways

Genomics has been pivotal in medical research – transgenic animal models have provided researchers with useful disease models; genetic screening has helped doctors diagnose patients; and, genomics has paved the way for advances in cancer research.

Genomics, however, has some drawbacks that make chemical genetics and the use of small molecules in biomedical research extremely important, especially in the areas of cancer research.

Read this paper to learn more about the burgeoning field of chemical genetics:

Chemical genetic approaches for the elucidation of signaling

 

Top Court in India Rejects Novartis Drug Patent

http://www.nytimes.com/2013/04/02/business/global/top-court-in-india-rejects-novartis-drug-patent.html?pagewanted=1&_r=0&nl=todaysheadlines&emc=edit_th_20130402

A few highlights from the article:

“The debate over global drug pricing is one of the most contentious issues between developed countries and the developing world. While poorer nations maintain they have a moral obligation to make cheaper, generic drugs available to their populations — by limiting patents in some cases — the brand name pharmaceutical companies contend the profits they reap are essential to their ability to develop and manufacture innovative medicines…

In Monday’s decision, India’s Supreme Court ruled that the patent that Novartis sought for Gleevec did not represent a true invention…

Leena Menghaney, a patient advocate at Doctors Without Borders, said that the ruling was a reprieve from more expensive medicines, but only for a while…”

The pricing of drugs is probably one of the most contentious issues between developed and developing nations. Countries like India, Argentina, Brazil, and Thailand that manufacture generic drug, which go on sale at affordable prices, have passed laws ameliorating the deleterious effects of the decreased expiration date on phony patents.

Although profits are essential to innovation in science, why are there so many me-too drugs (i.e. Nexium, statins, etc.)? And why are there fewer phase I clinical trials and a surge in phase 2 and 3, which only test the effect of slight variations on old drugs?

If you are interested in this issue you should read “The Truth About Drug Companies” by Marcia Angell.

MDGs and SDGs: A Shift in Global Development Philosophy?

The UN has committed to developing a set of Sustainable Development Goals (SDGs) that will build upon the Millennium Development Goals (MDGs), which end in 2015, in order to link the eradication of poverty, maternal mortality, and infectious diseases to the protection of the atmosphere, oceans, and land. As one of the scientists spearheading this effort, Johan Rockstroem, stated, “we are now at the point that the stable functioning of Earth systems is a prerequisite for a thriving global society and future development.” The recent drought in Somalia, the rising water levels, the acidification of the ocean, the air pollution in China and the UK, and the deforestation in South America are harbingers of not only environmental, but also socioeconomic, disasters. In order to address broad environmental concerns, a group of international scientists propose six SDGs: ensure thriving lives and livelihoods; sustainable food security; sustainable water security; universal clean energy; healthy and productive ecosystems; and governance for sustainable societies. The classic model of sustainable development since 1987 has focused on economic, social, and environmental factors, but has failed to integrate these three issues to meet the needs of the present while protecting the environment on which the general health and well being of current and future generations depend.


Despite the urgency to address global environmental concerns, some developing countries fear that a new focus on SDGs will divert aid from MDGs that have not yet been achieved and overburden the already sprawling developmental aid agenda. The proponents of the SDGS, however, argue that the SDGs extend many of the targets of the MDGs and work towards more long-term goals. Thus, the SDGs and MDGs do not operate within a different framework, but are intertwined: the SDG on thriving lives and livelihoods, for example, seeks to “end poverty and improve well-being through access to education, employment and information, better health and housing, and reduced inequality,” which is the focus of the MDGs. Although several scientific initiatives, such as the UN Environment Programme, the IHDP, and Future Earth are collaborating to develop the SDGs, it will be difficult to generate the necessary shift in global development agenda from addressing the MDG’s short term goals focusing on the social determinants of health to the SDG’s long term goals emphasizing the broad issues of sustainable development, which will require a multi-sectorial approach and a shift from donor/beneficiary country relationships to meaningful international partnerships that encourage policy coherency and global collaboration.