Category Archives: Uncategorized

First Hart lab publication!

Congratulations to all co-authors on our latest paper in ACS Biochemistry!

The lab surprised me with champagne and cake to celebrate, but first they scared the bejesus out of me by sending me this text “Errrr could you by change rush over to lab there’s a bit of a situation.” Thanks, Megalan!

Left to right: Sonya Lee ’22, Prof. Hart, Megalan Tso ’22 and Devin Biesbrock ’23

NIH AREA Grant

Chemistry Professor Katie Hart Wins NIH Grant

Brilliant scientists and athletes – the Hart Lab stays busy in and out of the lab

Check out these amazing women profiled in the Eph Spotlight:

https://ephsports.williams.edu/sports/wxc/video/EPH_SPOTLIGHT-_Emily_Harris_-Cross_Country_and_Track-

https://ephsports.williams.edu/EPH_SPOTLIGHT-_Lauren_Vostal_-19_Women-s_Basketball

Cynthia and Miranda honored at Protein Society 32nd Annual Symposium in Boston

Miranda, Cynthia and I had a great time at the Protein Society 32ndAnnual Symposium in Boston, MA! Miranda presented a poster and was chosen to give a talk. She received good questions and feedback from other students and experts in the field. Cynthia presented a poster and received a cash prize! Both Miranda and Cynthia were honored by the Society for their presentations during the meeting’s final reception. Way to go Hart Lab!

 

Miranda (fourth from left) and Cynthia (fifth from left) were honored by the Protein Society for their research.
Miranda gave a great talk about her thesis research!
Cynthia won the coveted poster award for her presentation (which included a cash prize!)

 

New digs

At the end of the Spring semester, we said “goodbye” to our beloved Bronfman and “hello” to the brand new South Science Center! After much hard work packing, moving, unpacking (and troubleshooting temperamental equipment), the Hart lab is once again live and ready to SCIENCE!

before

During

after

 

Welcome to the Hart Lab!

We are engaged in an arms race with pathogens. And we’re losing. Just as quickly as we can develop new antibiotics or antiviral treatments, resistant strains emerge – often within the year. Evolution, it turns out, doesn’t always take eons. In fact, we are watching microbes evolve in real time in clinics, on farms and in the natural environment, which gives us the opportunity to both study how evolution occurs on short timescales and learn how to combat drug resistance.

My lab studies how drug resistance evolves at the molecular level with a particular focus on protein stability. Many forms of drug resistance depend upon a small number of mutations that result in changes to a protein’s amino acid sequence. By investigating how these changes affect protein structure, stability and function, we can begin to understand how evolution works at the molecular level and leverage these insights to inform the design and implementation of new drug treatments.