Scholarly Publications (*indicates undergraduate authors)
Lee S,†* Okoye CN,†* Biesbrock D,* Harris EC,* Miyasaki KF,* Rilinger RG,* Tso M,* Hart KM. Natural and synthetic suppressor mutations defy stability-activity tradeoffs. Biochemistry, In Press. †co-first authors
Porter JR, Moeder KE,* Sibbald CA, Zimmerman MI, Hart KM, Greenberg MJ, Bowman GR. Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling. Biophysical Journal 116, 818-830 (2019).
Zimmerman MI,† Hart KM,† Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR. Prediction of new stabilizing mutations based on mechanistic insights from Markov state model. ACS Cen. Sci. 3, 1311-1321 (2017). †co-first authors
Hart KM, Moeder KE,* Ho CMW, Zimmerman MI, Frederick TE, Bowman GR. Designing small molecules to target cryptic pockets yields both positive and negative allosteric regulators. PloS One 12, e0178678 (2017).
Lim SA, Hart KM, Harms MJ, Marqusee, S. Evolutionary trend toward kinetic stability in the folding trajectory of RNases H. PNAS 113, 13045-13050 (2016).
Hart KM, Ho CMW, Dutta S, Gross ML, Bowman GR. Modeling proteins’ hidden conformations to predict antibiotic resistance. Nat. Comm. 7, 12965 (2016).
Hart KM, Reck M, Bowman GR, Wencewicz TA. Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance. MedChemComm 7, 118-127 (2016).
Bowman GR, Bolin ER, Hart KM, Maguire BC, Marqusee S. Discovery of multiple hidden allosteric sites by combining Markov state models and experiments. PNAS 112, 2734-2739 (2015).
Hart KM, Harms MJ, Schmidt BH, Elya C, Thornton JW, Marqusee S. Thermodynamic system drift in protein evolution. PloS Biology 12, e1001994 (2014).
Paulick MG, Hart KM, Brinner KM, Tjandra M, Charych DH, Zuckermann RN. Cleavable Hydrophilic Linker for One-Bead-One-Compound Sequencing of Oligomer Libraries by Tandem Mass Spectrometry. J. Comb. Chem. 8, 417-426 (2006).
Books
Kuldell N, Bernstein R, Ingram K, Hart KM. BioBuilder: Synthetic Biology in the Lab. Sebastopol, CA: O’Reilly Media, Inc. (2015).