{"id":159,"date":"2013-01-03T20:19:22","date_gmt":"2013-01-04T01:19:22","guid":{"rendered":"http:\/\/sites.williams.edu\/medjournal\/?p=159"},"modified":"2013-01-03T20:19:22","modified_gmt":"2013-01-04T01:19:22","slug":"obesity-in-mice-with-adipocyte-specific-deletion-of-clock-component-arntl","status":"publish","type":"post","link":"https:\/\/sites.williams.edu\/medjournal\/medical-research\/obesity-in-mice-with-adipocyte-specific-deletion-of-clock-component-arntl\/","title":{"rendered":"Obesity in mice with adipocyte-specific deletion of clock component Arntl"},"content":{"rendered":"<p>&#8220;Adipocytes store excess energy in the form of triglycerides and signal the levels of stored energy to the brain.&#8221; A recent studies shows \u00a0&#8220;that adipocyte-specific deletion of\u00a0<em>Arntl<\/em>\u00a0(also known as\u00a0<em>Bmal1<\/em>), a gene encoding a core molecular clock component, results in obesity in mice with a shift in the diurnal rhythm of food intake, a result that is not seen when the gene is disrupted in hepatocytes or pancreatic islets.&#8221;<\/p>\n<p>&#8220;Previous studies have shown that dysregulation of the feeding rhythm without an increase in total food intake can lead to obesity in rodents.&#8221;<\/p>\n<p>Click <a href=\"http:\/\/www.nature.com\/nm\/journal\/v18\/n12\/full\/nm.2979.html#\/discussion\">here<\/a> to read the article<\/p>\n<p>There was a tutorial last semester on molecular clocks. This is certainly a great read (or a leisurely perusal) if you are interested in molecular clocks and their impact on our health.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Adipocytes store excess energy in the form of triglycerides and signal the levels of stored energy to the brain.&#8221; A recent studies shows \u00a0&#8220;that adipocyte-specific deletion of\u00a0Arntl\u00a0(also known as\u00a0Bmal1), a gene encoding a core molecular clock component, results in obesity &hellip; <a href=\"https:\/\/sites.williams.edu\/medjournal\/medical-research\/obesity-in-mice-with-adipocyte-specific-deletion-of-clock-component-arntl\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[41936],"tags":[],"class_list":["post-159","post","type-post","status-publish","format-standard","hentry","category-medical-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/posts\/159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/comments?post=159"}],"version-history":[{"count":1,"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/posts\/159\/revisions"}],"predecessor-version":[{"id":160,"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/posts\/159\/revisions\/160"}],"wp:attachment":[{"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/media?parent=159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/categories?post=159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.williams.edu\/medjournal\/wp-json\/wp\/v2\/tags?post=159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}