{"id":61,"date":"2017-09-12T10:53:27","date_gmt":"2017-09-12T14:53:27","guid":{"rendered":"http:\/\/sites.williams.edu\/kmh8\/?page_id=61"},"modified":"2022-02-14T12:26:46","modified_gmt":"2022-02-14T17:26:46","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.williams.edu\/kmh8\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Scholarly Publications <\/strong>(*indicates undergraduate authors)<\/p>\n

Lee S,\u2020* Okoye CN,\u2020* Biesbrock D,* Harris EC,* Miyasaki KF,* Rilinger RG,* Tso M,*\u00a0Hart KM<\/strong><\/span>. Natural and synthetic suppressor mutations defy stability-activity tradeoffs<\/a>. Biochemistr<\/em>y, In Press.\u00a0\u2020co-first authors<\/em><\/p>\n

Porter JR, Moeder KE,* Sibbald CA, Zimmerman MI, Hart KM<\/strong><\/span>, Greenberg MJ, Bowman GR. Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling<\/a>. Biophysical Journal<\/em> 116, 818-830 (2019).<\/p>\n

Zimmerman MI,\u2020\u00a0Hart KM,<\/u><\/strong>\u2020\u00a0Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR.\u00a0Prediction of new stabilizing mutations based on mechanistic insights from Markov state model<\/span><\/a>. ACS Cen. Sci. <\/em>3, 1311-1321 (2017).\u00a0 \u00a0\u2020co-first authors<\/em><\/p>\n

Hart KM<\/u><\/strong>, Moeder KE,* Ho CMW, Zimmerman MI, Frederick TE, Bowman GR.\u00a0Designing small molecules to target cryptic pockets yields both positive and negative allosteric regulators<\/a>. PloS One <\/em>12, e0178678 (2017).<\/p>\n

Lim SA, Hart KM<\/u><\/strong>, Harms MJ, Marqusee, S.\u00a0Evolutionary trend toward kinetic stability in the folding trajectory of RNases H<\/a>. PNAS <\/em>113, 13045-13050 (2016).<\/p>\n

Hart KM<\/u><\/strong>, Ho CMW, Dutta S, Gross ML, Bowman GR.\u00a0Modeling proteins\u2019 hidden conformations to predict antibiotic resistance<\/a>. Nat. Comm.<\/em> 7, 12965 (2016).<\/p>\n

Hart KM<\/u><\/strong>, Reck M, Bowman GR, Wencewicz TA.\u00a0Tabtoxinine-\u03b2-lactam is a \u201cstealth\u201d \u03b2-lactam antibiotic that evades \u03b2-lactamase-mediated antibiotic resistance<\/a>. MedChemComm<\/em> 7, 118-127 (2016).<\/p>\n

Bowman GR, Bolin ER, Hart KM<\/u><\/strong>, Maguire BC, Marqusee S.\u00a0Discovery of multiple hidden allosteric sites by combining Markov state models and experiments<\/a>. PNAS<\/em> 112, 2734-2739 (2015).<\/p>\n

Hart KM<\/u><\/strong>, Harms MJ, Schmidt BH, Elya C, Thornton JW, Marqusee S.\u00a0Thermodynamic system drift in protein evolution<\/a>. PloS Biology<\/em> 12, e1001994 (2014).<\/p>\n

Paulick MG, Hart KM<\/u><\/strong>, Brinner KM, Tjandra M, Charych DH, Zuckermann RN.\u00a0Cleavable Hydrophilic Linker for One-Bead-One-Compound Sequencing of Oligomer Libraries by Tandem Mass Spectrometry<\/a>. J. Comb. Chem<\/em>. 8, 417-426 (2006).<\/p>\n

 <\/p>\n

Books<\/strong><\/p>\n

Kuldell N, Bernstein R, Ingram K, Hart KM<\/u><\/strong>.\u00a0BioBuilder: Synthetic Biology in the Lab<\/a><\/em>. Sebastopol, CA: O\u2019Reilly Media, Inc. (2015).<\/p>\n","protected":false},"excerpt":{"rendered":"

Scholarly Publications (*indicates undergraduate authors) Lee S,\u2020* Okoye CN,\u2020* Biesbrock D,* Harris EC,* Miyasaki KF,* Rilinger RG,* Tso M,*\u00a0Hart KM. Natural and synthetic suppressor mutations defy stability-activity tradeoffs. Biochemistry, In Press.\u00a0\u2020co-first authors Porter JR, Moeder KE,* Sibbald CA, Zimmerman MI, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1633,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-61","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/pages\/61","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/users\/1633"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/comments?post=61"}],"version-history":[{"count":10,"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/pages\/61\/revisions"}],"predecessor-version":[{"id":173,"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/pages\/61\/revisions\/173"}],"wp:attachment":[{"href":"https:\/\/sites.williams.edu\/kmh8\/wp-json\/wp\/v2\/media?parent=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}